Hexokinases

Supporting information

catalyze the first essential step of glucose metabolism, the conversion of glucose into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which has four isozymes designated hexokinase I, II, III and IV.

HK1 and HK2 are both localized to the outer mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
HK1 Human HK1 NM_000188 P19367
Mouse Hk1 NM_010438 P17710
Rat Hk1 NM_012734 P05708
HK2 Human HK2 NM_000189 P52789
Mouse Hk2 NM_013820 O08528
Rat Hk2 NM_012735 P27881

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