AMPK

Supporting information

AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of α- (catalytic) and β/γ- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP.

AMPK is regulated by phosphorylation at the Thr-172 residue of the α-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-β (CamKKβ). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.

To view external sources of pharmacological information for AMPK, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AMPKα1 Human PRKAA1 NM_006251 Q13131
Mouse Prkaa1 NM_001013367 Q5EG47
Rat Prkaa1 NM_019142 P54645
AMPKα2 Human PRKAA2 NM_006252 P54646
Mouse Prkaa2 NM_178143 Q8BRK8
Rat Prkaa2 NM_023991 Q09137
View all AMPK Gene Data »

Literature for AMPK

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
AMPK Signaling Pathway
AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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AMPK Pathway

AMPK Signaling Pathway

AMPK signaling is involved in the downstream cellular response to low levels of ATP. View pathway or download PDF today.

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