Supporting information

Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. This is a diverse class of enzymes and includes diacylglycerol lipase and lipoprotein lipase (E.C., and endothelial lipase (E.C.

Diacylglycerol lipase (DAGL) catalyzes the conversion of 1,2,diacylglycerol (DAG) into the endocannabinol, 2'arachidonylglycerol (2'AG). 2'AG is a cannabinoid receptor 1 (CB1) agonist and is involved in the inhibition of neurotransmitter release. There are two DAGL isoforms; DAGLα and DAGLβ. Both isoforms are associated with the plasma membrane and are stimulated by Ca2+. They are found throughout the central nervous system, where they appear to be targeted exclusively to post-synaptic neuronal membranes.

Endothelial lipase (LIPG) is a vascular lipase which is synthesized in endothelial cells. LIPG hydrolyzes the phospholipids of VLDL, chylomicrons and HDL; it also displays triglyceride lipase activity.

Lipoprotein lipase (LPL), like LIPG, is a vascular lipase, however it is not synthesized in endothelial cells. It is anchored to the capillary endothelium by proteoglycans and catalyzes the hydrolysis of triglycerides to release free fatty acids into the circulation. LPL therefore initiates the processing of triglyceride-rich lipoproteins such as chylomicrons and VLDL.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
DAGLα Human DAGLA NM_006133 Q9Y4D2
Mouse Dagla NM_198114 Q6WQJ1
Rat Dagla NM_001005886 Q5YLM1
DAGLβ Human DAGLB NM_139179 Q8NCG7
Mouse Daglb NM_144915 Q91WC9
Rat Daglb NM_001107120 P0C1S9
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Literature for Lipases

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Cancer Research Product Guide
Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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Cannabinoid Receptor Ligands Scientific Review

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Cannabinoid Scientific Review

Written by Roger Pertwee

Cannabinoid Receptor Ligands Scientific Review

Our Cannabinoid review gives an overview of the pharmacological ligands used to study the cannabinoid CB1 and CB2 receptors. Request copy or view PDF today.

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