Inositol lipids are important intracellular second messengers. Inositol phosphatases remove phosphate groups from inositol lipids and are involved in the phosphatidylinositol signaling pathway. Two examples of inositol phosphatases are Ins(1,4,5)P3 5-phosphatase (E.C. 126.96.36.199) and inositol monophosphatase (IMPase) (E.C. 188.8.131.52).
Ins(1,4,5)P3 5-phosphatase catalyzes the specific dephosphorylation of Ins(1,4,5)P4 in the 5 position to form Ins(1,3,4)P3. This enzyme requires Mg2+ for catalytic activity and is found in almost all tissues.
IMPase is essential for the de novo synthesis of myo-inositol, and for recycling of Ins(1,4,5)P3. IMPases are regulated in response to the metabolic need of inositol lipids. Structurally, IMPase exists as a homodimer that requires two metal cations (Mn2+ or Ca2+) for catalytic activity. The human IMPase 2 gene has been localized to chromosome 18p11.2 and this has been identified as a susceptibility region for bipolar disorder, schizophrenia and febrile seizures.View all products for Inositol Phosphatases »
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Literature for Inositol Phosphatases
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