Inositol lipids are important intracellular second messengers. Inositol phosphatases remove phosphate groups from inositol lipids and are involved in the phosphatidylinositol signaling pathway. Two examples of inositol phosphatases are Ins(1,4,5)P3 5-phosphatase (E.C. 126.96.36.199) and inositol monophosphatase (IMPase) (E.C. 188.8.131.52).
Ins(1,4,5)P3 5-phosphatase catalyzes the specific dephosphorylation of Ins(1,4,5)P4 in the 5 position to form Ins(1,3,4)P3. This enzyme requires Mg2+ for catalytic activity and is found in almost all tissues.
IMPase is essential for the de novo synthesis of myo-inositol, and for recycling of Ins(1,4,5)P3. IMPases are regulated in response to the metabolic need of inositol lipids. Structurally, IMPase exists as a homodimer that requires two metal cations (Mn2+ or Ca2+) for catalytic activity. The human IMPase 2 gene has been localized to chromosome 18p11.2 and this has been identified as a susceptibility region for bipolar disorder, schizophrenia and febrile seizures.View all products for Inositol Phosphatases »
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|View all Inositol Phosphatase Gene Data »|
Literature for Inositol Phosphatases
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Invasion and Metastasis
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.