Inositol Phosphatases

Supporting information

Inositol lipids are important intracellular second messengers. Inositol phosphatases remove phosphate groups from inositol lipids and are involved in the phosphatidylinositol signaling pathway. Two examples of inositol phosphatases are Ins(1,4,5)P3 5-phosphatase (E.C. 3.1.3.36) and inositol monophosphatase (IMPase) (E.C. 3.1.3.25).

Ins(1,4,5)P3 5-phosphatase catalyzes the specific dephosphorylation of Ins(1,4,5)P4 in the 5 position to form Ins(1,3,4)P3. This enzyme requires Mg2+ for catalytic activity and is found in almost all tissues.

IMPase is essential for the de novo synthesis of myo-inositol, and for recycling of Ins(1,4,5)P3. IMPases are regulated in response to the metabolic need of inositol lipids. Structurally, IMPase exists as a homodimer that requires two metal cations (Mn2+ or Ca2+) for catalytic activity. The human IMPase 2 gene has been localized to chromosome 18p11.2 and this has been identified as a susceptibility region for bipolar disorder, schizophrenia and febrile seizures.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
IMPase 1 Human IMPA1 NM_005536 P29218
Mouse Impa1 NM_018864 O55023
Rat Impa1 NM_032057 P97618
IMPase 2 Human IMPA2 NM_014214 O14732
Mouse Impa2 NM_053261 Q91UZ5
Rat Impa2 NM_172224 Q8CIN7
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Literature for Inositol Phosphatases

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