Ribonucleotide Reductase

Supporting information

Ribonucleotide Reductases (RNRs) are iron-dependent reductase enzymes that catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis. There are three classes of RNRs (Classes I - III), but only class I are present in eukaryotes. Ribonucleotide reductase is composed of two subunits; RNR1 and RNR2, which form heterodimeric tetramers and a unique feature of note is the requirement of a free radical for catalytic activity.

RNRs are allosterically regulated by the relative concentrations of ATP:dATP. In addition, to ensure a balanced supply of nucleotides for DNA synthesis, RNR substrate specificity is modulated by ATP and GTP binding to the active site. Perturbations in RNR expression is a hallmark of malignant transformation and many cancer therapies target this enzyme.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
RRM1 Human RRM1 NM_001033 P23921
Mouse Rrm1 NM_009103 P07742
Rat Rrm1 NM_001013236 Q5U2Q5
RRM2 Human RRM2 NM_001034 P31350
Mouse Rrm2 NM_009104 P11157
Rat Rrm2 NM_001025740 Q4KLN6
View all Ribonucleotide Reductase Gene Data »

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