The Na+/Ca2+ exchanger (NCX) is a low affinity, high capacitance calcium antiporter membrane protein that functions to regulate intracellular calcium concentrations. It is located on the plasma, mitochondrial and endoplasmic reticular membranes of excitable cells. Using the electrochemical gradient of Na+, one Ca2+ ion is transported out of the cell in exchange for three Na+ ions.
The Na+/Ca2+ exchanger compliments the high affinity, low capacitance Ca2+-ATPase and together, they are involved in a variety of cellular functions including control of neurosecretion, relaxation of cardiac muscle, maintenance of intracellular Ca2+ stores in the endoplasmic and sarcoplasmic reticuli and excitation-contraction coupling. Under normal physiological conditions, Na+/Ca2+ exchangers export Ca+ from the cell. However, under cellular stress, such as excitotoxicity, they can switch to 'reverse mode,' which has a protective effect.View all products for Na+/Ca2+ Exchanger »
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A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Thrombosis and Hemostasis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Heart Failure
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