Angiotensin AT1 Receptors

Supporting information

The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.

Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).

To view external sources of pharmacological information for Angiotensin AT1 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AT1A Human AGTR1 NM_000685 P30556
Mouse Agtr1a NM_177322 P29754
Rat Agtr1a NM_030985 P25095
AT1B Mouse Agtr1b NM_175086 P29755
Rat Agtr1b NM_031009 P29089

Literature for Angiotensin AT1 Receptors

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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  • Thrombosis and Hemostasis
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Cardiovascular Research Product Guide
GPCR Product Listing

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GPCR Product Listing
Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

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Peptide Hormone Receptors Product Listing
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Cardiovascular Life Science Poster

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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