Nicotinic (α7) Receptors

More Information »Alpha 7 (α7) is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. The α7 nAChR is prominent in the hippocampus, found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.

Nicotinic (α7) Receptor Products

Agonists
Cat.No.
Product Name / Activity
4234 4BP-TQS
Allosteric agonist at α7 nAChR
4341 A 582941
Partial agonist at α7 nAChR
4477 A 844606
Selective α7 nAChR partial agonist
3964 AR-R 17779 hydrochloride
α7-selective agonist
3549 3-Bromocytisine
Potent agonist of α4β4, α4β2 and α7 nACh receptors
2241 DMAB-anabaseine dihydrochloride
Partial agonist at α7 nAChR; also α4β2 antagonist
4557 GTS 21 dihydrochloride
Partial agonist at α7 nAChR
3092 PHA 543613 hydrochloride
Potent and selective α7 nAChR agonist
3134 PHA 568487
α7-selective agonist
2303 PNU 282987
Selective α7 nAChR agonist
3518 S 24795
Partial agonist at α7 nAChR
4441 SEN 12333
α7 nAChR agonist; histamine H3 antagonist
5559 SSR 180711 hydrochloride
Partial agonist at α7 nAChR
2518 TC 1698 dihydrochloride
α7-selective agonist
Antagonists
Cat.No.
Product Name / Activity
2133 α-Bungarotoxin
α7 subtype-selective nAChR antagonist
3405 COG 133
ApoE peptide fragment; α7 nAChR antagonist
3119 α-Conotoxin ImI
α7 and α9 selective nAChR antagonist
1029 Methyllycaconitine citrate
α7 neuronal nicotinic receptor antagonist
1356 MG 624
α7 neuronal nicotinic receptor antagonist
2459 Tropisetron hydrochloride
α7 partial agonist; inhibits α3β4 nAChR. Also potent 5-HT3 receptor antagonist
Modulators
Cat.No.
Product Name / Activity
4571 A 867744
Positive allosteric modulator of α7 nAChR
3837 CCMI
Positive allosteric modulator of α7 nAChR
1260 Ivermectin
Allosteric modulator of α7 nicotinic receptors
4141 LY 2087101
Potentiator of α7 nAChRs
2995 NS 1738
Positive allosteric modulator of α7 nAChR; active in vivo
2498 PNU 120596
Positive allosteric modulator of α7 nAChR; active in vivo
4233 TQS
Positive allosteric modulator of α7 nAChRs
Other
Cat.No.
Product Name / Activity
3091 FR 236924
Enhances α7 nAChR activity; PKCε activator
5156 Ivermectin B1a-d2
Deuterated ivermectin B1a (Cat. No. 1260)
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