Casein Kinase 1

Supporting information

Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: α, β, γ1, γ2, γ3, δ and ε. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport.

CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1α is thought to phosphorylate β-catenin as part of its degradation process. Upon binding of Wnt to its receptor (Frizzled) CK1ε phosphorylates the intracellular signaling protein, Dishevelled and CK1γ directly phosphorylates the LRP5/6 co-receptor. These actions of CK1 facilitate signal transduction to the transcription factor, TCF, which mediates transcription of Wnt regulated genes. Similarly, CK1α plays a role in regulating Hh signaling by phosphorylating the signaling effector Ci-155 in the Hh unbound state, and then when Hh binds to Patched, CK1α phosphorylates the 7-TM co-receptor, Smoothened.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CK1α Human CSNK1A1 NM_001892 P48729
Mouse Csnk1a1 NM_146087 Q8BK63
Rat Csnk1a1 NM_053615 P97633
CK1δ Human CSNK1D NM_139062 P48730
Mouse Csnk1d NM_027874 Q9DC28
Rat Csnk1d NM_139060 Q06486
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Literature for Casein Kinase 1

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