Abl Kinase

Supporting information

The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2) subtypes. c-Abl is localized at several subcellular sites including the nucleus, cytoplasm, mitochondria and endoplasmic reticulum, where it interacts with a large variety of cellular proteins including signaling adaptors, kinases, phosphatases, cell cycle regulators, transcription factors and cytoskeletal proteins.

Due to its diverse range of targets, c-Abl has been implicated in many cellular processes including regulation of cell growth and survival, oxidative stress and DNA-damage responses, and actin dynamics and cell migration. The Abl family have significant structural homology to the Src tyrosine kinase family, but have a unique long carboxy-terminal extension that contains protein-protein interaction sites and acts as the binding site for targets such as ATM, p53 and pRb. c-Abl is medically important as there is a causal link between the Abl-Bcr fusion protein (caused by a t(9,22) translocation) and development of chronic myeloid leukemia.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Abl Human ABL1 NM_007313 P00519
Mouse Abl1 NM_001112703 P00520
Rat Abl1 XM_231137 Q2PYT3
Arg Human ABL2 NM_005158 P42684
Mouse Abl2 NM_009595 Q4JIM5
Rat Abl2 NM_001107186 XP_222768

Literature for Abl Kinase

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Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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