5-HT2A Receptors

More Information »Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, hippocampus, and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in the control of appetite.

5-HT2A Receptor Products

Agonists
Cat.No.
Product Name / Activity
2643 DOI hydrochloride
Mixed 5-HT2A/2C agonist
5171 NBOH-2C-CN hydrochloride
High affinity, selective 5-HT2A agonist
2201 PNU 22394 hydrochloride
5-HT2C agonist and 5-HT2A/2B partial agonist
2592 TCB-2
Potent, high affinity 5-HT2A agonist
Antagonists
Cat.No.
Product Name / Activity
1809 Altanserin hydrochloride
5-HT2A receptor antagonist
5584 Aripiprazole
5-HT2A antagonist; also D2 and 5-HT1A receptor partial agonist
4468 AT 1015
Long-acting 5-HT2A antagonist
0444 Clozapine
5-HT2A/2C antagonist. Also dopamine antagonist
4936 Clozapine N-oxide
Clozapine (Cat. No. 0444) metabolite
3428 DMT
5-HT2A antagonist. Also SERT inhibitor and endogenous σ1 ligand
4480 DV 7028 hydrochloride
Selective 5-HT2A antagonist; antithrombotic
4470 EMD 281014 hydrochloride
Selective 5-HT2A antagonist
4958 Eplivanserin hemifumarate
Potent and selective 5-HT2A antagonist
0523 4F 4PP oxalate
Selective 5-HT2A antagonist
2645 Fananserin
5-HT2A antagonist. Also D4 antagonist
0908 Ketanserin tartrate
Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
4173 MDL 100907
Potent and selective 5-HT2A antagonist
0870 MDL 11,939
5-HT2A antagonist
2495 Melperone hydrochloride
5-HT2A/D2 receptor antagonist; neuroleptic
1644 Mesulergine hydrochloride
5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist
2777 Nefazodone hydrochloride
5-HT2A antagonist and 5-HT uptake inhibitor. Antidepressant
4493 Paliperidone
Atypical antipsychotic; 5-HT2A and D2 antagonist
2735 PNU 96415E
5-HT2A and D4 antagonist; antipsychotic
1742 R-96544 hydrochloride
Potent, selective 5-HT2A antagonist
2865 Risperidone
5-HT2A antagonist
3739 Sarpogrelate hydrochloride
Selective 5-HT2A antagonist
0995 Spiperone hydrochloride
5-HT2A antagonist. Also D2-like antagonist
3085 Ziprasidone hydrochloride
5-HT2A/D2 antagonist; atypical antipsychotic
3996 Zotepine
5-HT2A/D2 antagonist; atypical antipsychotic
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