5-HT2B Receptors

Supporting information

Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. The functions of 5-HT2B receptors include regulation of differentiation and proliferation of the embryonic and adult heart, gastrointestinal contraction and endothelium-dependent relaxation. Furthermore, 5-HT2B receptor knockout mice exhibit gross heart defects and 5-HT2B overexpression leads to ventricular hypertrophy. The human 5-HT2B receptor gene has been localized to chromosome 2 (2q36.3-q37.1).

To view external sources of pharmacological information for 5-HT2B Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR2B NM_000867 P41595
Mouse Htr2b NM_008311 Q02152
Rat Htr2b NM_017250 P30994

Literature for 5-HT2B Receptors

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