Leptin Receptors

Supporting information

Leptin was initially thought to have a role in energy homeostasis and obesity. More recently, it has also been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and the immune system. Leptin acts via leptin receptors, which are transmembrane catalytic receptors found on NPY/AgRP and α-MSH/CART neurons in hypothalamic nuclei.

Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms; Ob-Ra to Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression.

Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human LEPR NM_002303 P48357
Mouse Lepr NM_001122899 P48356
Rat Lepr NM_012596 Q9JHF4

Literature for Leptin Receptors

Peptides Involved in Appetite Modulation Scientific Review

A synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis, outlining the putative roles of most of the known proteins and lists compounds available from Tocris.

Download PDF | View all reviews
Peptides Involved in Appetite Modulation Scientific Review
Gut Hormones Life Science Poster

Written by Victoria Taylor et al, this poster summarizes the major gut hormones and neuropeptide modulators that influence digestion, appetite and energy expenditure. The intracellular targets of stimulatory and inhibitory hormones and the role of the hypothalamus in signal integration are also described. Compounds available from Tocris are listed.

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Gut Hormones Life Science Poster

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Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

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Gut Hormones and the Regulation of Appetite

Written by V.J. Taylor et al

Gut Hormones Life Science Poster

Our Gut Hormones and the Regulation of Appetite poster gives an overview of the neuropeptide modulators and gut hormones that influence appetite. Request copy today.

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