Supporting information

Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme, telomerase reverse transcriptase (TERT). Telomerase adds small repeat sequences of DNA (TTAGGG) to the end of chromosomes - multiple repeats of this hexanucleotide sequence over a 5kb span are known as a telomere.

During normal cellular replication, telomeres are eroded and thus protect the coding sequences of the DNA. The erosion of telomeric sequences is thought to form the basis of the cellular clock which eventually signals for the cell to exit the cell cycle and undergo senescence. Expression of telomerase is low in most normal cells although it is thought to be active in embryonic cells and some rapidly dividing cells of the immune system. Overexpression of telomerase is key component of the transformation process in many malignant cancer cells.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TERT Human TERT NM_198255 O14746
Mouse Tert NM_009354 O70372
Rat Tert NM_053423 Q673L6
TERC Human TERC NR_001566 602322
Mouse Terc NR_001579 -
Rat Terc NR_001567 -
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Literature for Telomerase

Cancer Research Product Guide

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