Telomerase

Supporting information

Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme, telomerase reverse transcriptase (TERT). Telomerase adds small repeat sequences of DNA (TTAGGG) to the end of chromosomes - multiple repeats of this hexanucleotide sequence over a 5kb span are known as a telomere.

During normal cellular replication, telomeres are eroded and thus protect the coding sequences of the DNA. The erosion of telomeric sequences is thought to form the basis of the cellular clock which eventually signals for the cell to exit the cell cycle and undergo senescence. Expression of telomerase is low in most normal cells although it is thought to be active in embryonic cells and some rapidly dividing cells of the immune system. Overexpression of telomerase is key component of the transformation process in many malignant cancer cells.

View all products for Telomerase »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TERT Human TERT NM_198255 O14746
Mouse Tert NM_009354 O70372
Rat Tert NM_053423 Q673L6
TERC Human TERC NR_001566 602322
Mouse Terc NR_001579 -
Rat Terc NR_001567 -
View all Telomerase Gene Data »

Literature for Telomerase

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.