Aryl Hydrocarbon Receptors

Supporting information

Aryl hydrocarbon receptors (AHRs) are cytosolic transcription factors that exist bound to co-chaperones in the resting state (Hsp90, prostaglandin E synthase 3 and hepatitis B virus X-associated protein 2). Ligand binding causes the co-chaperones to dissociate, allowing AHR to translocate to the nucleus, dimerize with AHR nuclear translocator (ARNT) and alter transcription of target genes.

AHR is an evolutionary conserved receptor that has roles in cell proliferation and differentiation and induction of xenobiotic-metabolizing enzymes (for example CYP1A1). The human gene encoding the aryl hydrocarbon receptor has been localized to chromosome 7p15.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human AHR NM_001621 P35869
Mouse Ahr NM_013464 Q8R4S5
Rat Ahr NM_013149 P41738

Literature for Aryl Hydrocarbon Receptors

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