Supporting information

Cyclic adenosine monophosphate (cAMP) is an important second messenger that modifies the rate of some enzyme-catalyzed reactions in specific tissues, generating various metabolic responses. cAMP formation from ATP is catalyzed by adenylyl cyclase. Adenylyl cyclase is activated by Gs-protein-coupled receptors and inhibited by Gi-protein-coupled receptors.

cAMP degradation to 5'-AMP is catalyzed by increasing cytosolic Ca2+ levels and by phosphodiesterases. cAMP activates protein kinase A and Epac (exchange protein directly activated by cAMP) to mediate its intracellular effects. cAMP is involved in a variety of signaling pathways including those that regulate glycogen, glucose and lipid metabolism.

Dysregulation of cAMP has been implicated in tumorigenesis, diabetes and cardiovascular disease. More recently, it has been proposed that cAMP has a physiological role in prefrontal cortex functioning.

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Cancer Research Product Guide

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