NF-κB and IκB

Supporting information

NF-κB (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immune response to infection. In unstimulated cells NF-κB dimers are sequestered inactively in the cytoplasm by a protein complex called inhibitor of kappa B (IκB). IκB inactivates NF-κB by masking the nuclear localization signals (NLS).

Activation of NF-κB occurs via degradation of IκB, a process that is initiated by its phosphorylation by IκB kinase (IKK). Phosphorylated IκB becomes dissociated from NF-κB, unmasking the NLS. Phosphorylation also results in IκB ubiquitination and targeting to the proteasome. NF-κB can now enter the nucleus and regulate gene expression. NF-κB turns on expression of IκB forming a negative feedback loop.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NF-κB1 (p105/p50) Human NFKB1 NM_003998 P19838
Mouse Nfkb1 NM_008689 P25799
Rat Nfkb1 L26267 Q63369
NF-κB2 (p100/p52) Human NFKB2 NM_002502 Q00653
Mouse Nfkb2 NM_019408 Q9WTK5
Rat Nfkb2 NM_001008349 Q5U2Z4
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Literature for NF-κB and IκB

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Cancer Research Product Guide
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Asthma Life Science Poster
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View pathway | Download PDF

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

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NF-κB Pathway

NF-κB Signaling Pathway

Signals through the NF-κB pathway are important in the inflammation and the adaptive and innate immune response. View pathway or download PDF today.

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