STATs

Supporting information

STATs (signal transducers and activators of transcription) are a family of seven transcription factors that form part of the JAK-STAT signaling cascade. This cascade is the basis of the signal transduction mechanism for many cytokine receptors. Once activated by phosphorylation by JAKs, STATs translocate to the nucleus.

Accumulation of STATs in the nucleus is both rapid and tightly controlled. A number of factors regulate the JAK-STAT pathway including STAT dephosphorylation by phosphatases, altered nuclear import-export dynamics of STAT, and STAT gene activation antagonists such as SOCS (suppressors of cytokine signaling) and PIAS (Protein Inhibitors of Activated STATs).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
STAT1 Human STAT1 NM_007315 P42224
Mouse Stat1 NM_009283 P42225
Rat Stat1 NM_032612 Q9QXK0
STAT2 Human STAT2 NM_005419 P52630
Mouse Stat2 NM_019963 Q9WVL2
Rat Stat2 NM_001011905 Q5XI26
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Literature for STATs

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Request copy | Download PDF | View all Product Guides & Listings
Immunology Product Listing
JAK-STAT Signaling Pathway
JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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JAK-STAT Pathway

JAK-STAT Signaling Pathway

JAK-STAT signaling is involved in many fundamental cellular processes such as cell proliferation and hematopoiesis. View pathway or download PDF today.

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