Post-translational Modifications

Supporting information

Post-translational modifications are chemical changes to a protein that occur after translation. They widen the range of functions of the final protein. Many of these protein modifications occur in the rough endoplasmic reticulum (RER). There are five types of post-translational modifications:

  1. Formation of disulfide bridges
  2. Proper folding
  3. Addition and processing of carbohydrates
  4. Specific proteolytic cleavage
  5. Assembly into multimeric proteins

Examples of specific post-translational modifications include phosphorylation, sumolyation, ubiquitination, acetylation, methylation, glycosylation, hydroxylation, oxidation and deamination (conversion of arginine to citrulline). As all proteins begin with methionine, many have this first amino acid cleaved off during post-translational modification. This process occurs predominantly in the ER, Golgi and secretory vesicles.

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Literature for Post-translational Modifications

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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