Cell Adhesion Molecules

Supporting information

Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.

There are four major families of cell adhesion molecules:

  1. Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this family include neural cell adhesion molecule (NCAM) and intracellular adhesion molecule (ICAM).
  2. Selectins - Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).
  3. Integrins - bind IgSFs and extracellular matrix ligands (e.g. collagen, laminin) and regulate focal adhesion kinase and Src family kinase activity.
  4. Cadherins - Ca2+-dependent CAMs that are important in cell-cell junctions. Examples include E-cadherin (endothelial), P-cadherin (placental) and N-cadherin (neural).
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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NCAM1 Human NCAM1 NM_000615 Q59FL7
Mouse Ncam1 NM_001081445 P13595
Rat Ncam1 NM_031521 Q6LDL9
NCAM2 Human NCAM2 NM_004540 O15394
Mouse Ncam2 NM_010954 O35136
Rat Ncam2 NM_203409 Q6RKB2
View all Adhesion Molecule Gene Data »

Literature for Cell Adhesion Molecules

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Angiogenesis Life Science Poster

Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.

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Angiogenesis Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

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