Cell Adhesion Molecules
Cellular adhesion molecules (CAMs) are a large family of transmembrane proteins that link the cytoskeleton and intracellular signaling cascades with the extracellular environment. Cell adhesion molecules have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer.
There are four major families of cell adhesion molecules:
- Immunoglobulin Superfamily (IgSF) CAMs - bind to integrins and members of this family include neural cell adhesion molecule (NCAM) and intracellular adhesion molecule (ICAM).
- Selectins - Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet).
- Integrins - bind IgSFs and extracellular matrix ligands (e.g. collagen, laminin) and regulate focal adhesion kinase and Src family kinase activity.
- Cadherins - Ca2+-dependent CAMs that are important in cell-cell junctions. Examples include E-cadherin (endothelial), P-cadherin (placental) and N-cadherin (neural).
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|View all Adhesion Molecule Gene Data »|
Literature for Cell Adhesion Molecules
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Invasion and Metastasis
Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.Request copy | View all posters
Find multiple products by catalog number
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands