Checkpoint Control Kinases

Supporting information

Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed. Checkpoint control kinases function to halt the cell cycle at these critical points. Examples of checkpoint control kinases include ATM, ATR, DNA-PK, Chk1, Chk2, Wee1 and mTOR.

For a cell to progress through the cycle and replicate, it must pass through checkpoints between phases to ensure that DNA is replicated correctly and that chromosomes segregate. These checkpoints may stop the cell cycle after DNA damage, loss of DNA replication or disruption of the mitotic spindle, in order for repair processes to take place. If cells containing damaged DNA were to divide, the errors would be transmitted to daughter cells, generating genomic instability and resulting in tumorigenesis or apoptosis.

View all products for Checkpoint Control Kinases »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ATM Human ATM NM_000051 Q13315
Mouse Atm NM_007499 Q62388
Rat Atm NM_001106821 NP_001100291
ATR Human ATR NM_001184 Q13535
Mouse Atr NM_019864 Q9JKK8
Rat Atr XM_236563 -
View all Checkpoint Control Kinase Gene Data »

Literature for Checkpoint Control Kinases

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Request copy | Download PDF | View all Product Guides & Listings
Kinases Product Listing

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.