Mitosis

Supporting information

Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell.

Mitosis is split into five phases:

  1. Prophase - Chromatin condenses to form chromosomes. Centrosomes begin to migrate to opposite poles of the cell.
  2. Prometaphase - The nuclear envelope breaks down and centrosomes are situated at opposite poles of the cell. Sister chromatids attach to the microtubule spindles.
  3. Metaphase - Chromosomes align along the equatorial plane.
  4. Anaphase - The sister chromatids separate and are pulled to opposite poles of the cell along the microtubule spindles.
  5. Telophase - A new nuclear envelope forms around each set of sister chromatids. The chromatids decondense to chromatin and mitotic spindles start to break down.

Cytokinesis is a separate process that follows mitosis in order to complete cell division. It involves cleavage of the cytoplasm due to contraction of actin microfilaments that form a ring around the equator of the cell. This results in the formation of two daughter cells, each identical to the parent, that enter interphase at G0.

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Literature for Mitosis

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Cell Cycle & DNA Damage Repair Life Science Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

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Cell Cycle & DNA Damage Repair Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Life Science Poster

Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death. Request copy or view PDF today.

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