Mitosis

Supporting information

Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell.

Mitosis is split into five phases:

  1. Prophase - Chromatin condenses to form chromosomes. Centrosomes begin to migrate to opposite poles of the cell.
  2. Prometaphase - The nuclear envelope breaks down and centrosomes are situated at opposite poles of the cell. Sister chromatids attach to the microtubule spindles.
  3. Metaphase - Chromosomes align along the equatorial plane.
  4. Anaphase - The sister chromatids separate and are pulled to opposite poles of the cell along the microtubule spindles.
  5. Telophase - A new nuclear envelope forms around each set of sister chromatids. The chromatids decondense to chromatin and mitotic spindles start to break down.

Cytokinesis is a separate process that follows mitosis in order to complete cell division. It involves cleavage of the cytoplasm due to contraction of actin microfilaments that form a ring around the equator of the cell. This results in the formation of two daughter cells, each identical to the parent, that enter interphase at G0.

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Cancer Research Product Guide

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