Inhibitor of Apoptosis

Supporting information

Inhibitors of apoptosis (IAP) are a family of proteins that are the major regulators of apoptosis through their interaction with the various components of the apoptotic signaling cascades. Originally discovered in baculovirus, the human homologs are sometimes described as baculovirus IAP repeat containing (BIRC) proteins.

There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), X-chromosome linked IAP (XIAP or BIRC4) and survivin (BIRC5). cIAP-1 and 2 function through interaction with TNF receptors and by binding to the mitochondrial protein, SMAC, preventing it binding to XIAP. Thought to be the most potent apoptosis suppressor, XIAP, directly binds and inhibits caspases -3, -7 and -9. Survivin, which also binds to several caspases, is up-regulated in a many tumor cell types.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NAIP Human NAIP NM_004536 Q13075
Mouse Naip1 NM_008670 Q9QWK5
Rat Naip2 XM_226742 Q8R4U8
c-IAP-1 Human BIRC2 NM_001166 Q13490
Mouse Birc2 NM_007465 Q62210
Rat Birc2 NM_021752 O88642
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Literature for Inhibitor of Apoptosis

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Cancer Research Product Guide
Programmed Cell Death Life Science Poster

Written by Bram van Raam & Guy Salvesen, this poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

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Programmed Cell Death Life Science Poster
Apoptosis Signaling Pathway
Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

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