Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

Apoptosis Inducing Products

Product Name / Activity
1229 Actinomycin D
Antineoplastic antibiotic
5330 AEG 40730 dihydrochloride
IAP antagonist; induces apoptosis
4846 Apicidin
Potent histone deacetylase inhibitor; induces apoptosis
2098 Apoptosis Activator 2
Selectively induces tumor cell apoptosis
3367 AT 101
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
4810 BAM 7
Selective Bax activator; induces Bax-mediated apoptosis
3681 Bendamustine hydrochloride
Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906 Betulinic acid
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5791 Bz 423
ATP synthase inhibitor; proapoptotic
2489 C 75
Induces apoptosis and exhibits anti-tumor activity
2626 Carboplatin
DNA cross-linking antitumor agent
5144 CFM 4
CARP-1 mimetic; proapoptotic
5804 Chaetoglobosin A
Selective apoptosis inducer of CLL cells; antibiotic
3868 CHM 1
Potent antitumor agent; inducer of apoptosis
5800 CHMFL-FLT3-122
Induces apoptosis; FLT3 inhibitor
2251 Cisplatin
DNA-alkylating antitumor agent
5292 Cladribine
Deoxyadenosine analog; pro-apoptotic
5973 CP 724714
Potent and selective ErbB2 inhibitor; promotes tumor apoptosis
2841 Curcumin
Antitumor, anti-inflammatory and antioxidant
4091 Cyclophosphamide
Alkylating agent; chemotherapeutic
2137 2,3-DCPE hydrochloride
Selectively induces cancer cell apoptosis
1770 Deguelin
Anticancer and antiviral agent; chemopreventive and pro-apoptotic
2252 Doxorubicin hydrochloride
Antitumor antibiotic agent; induces apoptosis
4808 FK 866 hydrochloride
Non-competitive and potent NAMPT inhibitor; induces apoptosis and autophagy
3495 Fludarabine
Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
3590 Gambogic acid
Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
3603 Kaempferol
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
1807 2-Methoxyestradiol
Apoptotic and antiangiogenic agent
3258 Mitomycin C
DNA cross-linking antitumor agent
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine
Antiproliferative agent; exhibits pro-apoptotic effects
4566 NSC 687852
Inhibitor UCHL5 and USP14; induces apoptosis
6026 Oleanolic acid
Selective GPBA receptor (TGR5) partial agonist; apoptosis inducer
3427 Oncrasin 1
Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623 Oxaliplatin
DNA cross-linking antitumor agent
4643 PCI 34051
Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines
4396 Piperlongumine
Induces apoptosis; increases p53 and ROS levels in cancer cells
4761 Plumbagin
Induces apoptosis; anticancer
5359 Rifaximin
Apoptosis inducer; pregnane X receptor agonist and antibiotic
5314 SMBA 1
High affinity and selective activator of Bax
1621 Streptozocin
DNA alkylator; antitumor and induces diabetes
2706 Temozolomide
DNA-methylating antitumor agent
3909 Toceranib
Potent PDGFR and VEGFR inhibitor; induces apoptosis
4038 TW 37
Bcl-2 inhibitor; induces apoptosis

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Cancer Research Product Guide

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

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