Apoptosis Inducers

Apoptosis inducers exhibit pro-apoptotic effects through a variety of mechanisms, including DNA cross-linking, inhibition of antiapoptotic proteins and activation of caspases. These inducers may target a specific cellular process in order to induce antitumor or antineoplastic effects.

Apoptosis Inducing Products

 
Cat.No.
Product Name / Activity
1229 Actinomycin D
Antineoplastic antibiotic
5330 AEG 40730 dihydrochloride
IAP antagonist; induces apoptosis
4846 Apicidin
Potent histone deacetylase inhibitor; induces apoptosis
2098 Apoptosis Activator 2
Selectively induces tumor cell apoptosis
3367 AT 101
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
4810 BAM 7
Selective Bax activator; induces Bax-mediated apoptosis
3681 Bendamustine hydrochloride
Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906 Betulinic acid
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5791 Bz 423
ATP synthase inhibitor; proapoptotic
2489 C 75
Induces apoptosis and exhibits anti-tumor activity
2626 Carboplatin
DNA cross-linking antitumor agent
5144 CFM 4
CARP-1 mimetic; proapoptotic
5804 Chaetoglobosin A
Selective apoptosis inducer of CLL cells; antibiotic
3868 CHM 1
Potent antitumor agent; inducer of apoptosis
5800 CHMFL-FLT3-122
Induces apoptosis; FLT3 inhibitor
2251 Cisplatin
DNA-alkylating antitumor agent
5292 Cladribine
Deoxyadenosine analog; pro-apoptotic
5973 CP 724714
Potent and selective ErbB2 inhibitor; promotes tumor apoptosis
2841 Curcumin
Antitumor, anti-inflammatory and antioxidant
4091 Cyclophosphamide
Alkylating agent; chemotherapeutic
2137 2,3-DCPE hydrochloride
Selectively induces cancer cell apoptosis
1770 Deguelin
Anticancer and antiviral agent; chemopreventive and pro-apoptotic
2252 Doxorubicin hydrochloride
Antitumor antibiotic agent; induces apoptosis
4808 FK 866 hydrochloride
Non-competitive and potent NAMPT inhibitor; induces apoptosis and autophagy
3495 Fludarabine
Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
3590 Gambogic acid
Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
3603 Kaempferol
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
1807 2-Methoxyestradiol
Apoptotic and antiangiogenic agent
3258 Mitomycin C
DNA cross-linking antitumor agent
5231 MPC 6827 hydrochloride
Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine
Antiproliferative agent; exhibits pro-apoptotic effects
4566 NSC 687852
Inhibitor UCHL5 and USP14; induces apoptosis
6026 Oleanolic acid
Selective GPBA receptor (TGR5) partial agonist; apoptosis inducer
3427 Oncrasin 1
Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623 Oxaliplatin
DNA cross-linking antitumor agent
4643 PCI 34051
Potent and selective histone deacetylase 8 (HDAC8) inhibitor; induces apoptosis in T cell-derived cell lines
4396 Piperlongumine
Induces apoptosis; increases p53 and ROS levels in cancer cells
4761 Plumbagin
Induces apoptosis; anticancer
5359 Rifaximin
Apoptosis inducer; pregnane X receptor agonist and antibiotic
5314 SMBA 1
High affinity and selective activator of Bax
1621 Streptozocin
DNA alkylator; antitumor and induces diabetes
2706 Temozolomide
DNA-methylating antitumor agent
3909 Toceranib
Potent PDGFR and VEGFR inhibitor; induces apoptosis
4038 TW 37
Bcl-2 inhibitor; induces apoptosis

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

divider line

Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.