Retinoid X Receptors

Supporting information

Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding efficiency of its partner.

Despite numerous studies, the physiological role of RXRs have yet to been fully elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR signaling pathway exists.

There are three RXR subtypes; RXRα, RXRβ and RXRγ, each with two major isoforms (1 and 2). RXRα is expressed in the liver, kidney, epidermis and intestine, RXRβ is widely distributed and RXRγ is restricted to muscle, pituitary gland and certain parts of the brain.

To view external sources of pharmacological information for Retinoid X Receptors, please click here: BJP Guide

View all products for Retinoid X Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
RXRα Human RXRA NM_002957 P19793
Mouse Rxra NM_011305 P28700
Rat Rxra NM_012805 Q05343
RXRβ Human RXRB NM_021976 P28702
Mouse Rxrb NM_011306 P28704
Rat Rxrb NM_206849 P49743
View all Retinoid X Receptor Gene Data »

Literature for Retinoid X Receptors

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
Request copy | Download PDF | View all Product Guides & Listings
Nuclear Receptors Product Listing
Retinoid Receptors Scientific Review

A summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Compounds available from Tocris are listed.

Request copy | Download PDF | View all reviews
Retinoid Receptors Scientific Review

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

RXR and RAR Review

Written by Alexander Moise

Retinoid Receptors Scientific Review

Our Retinoid Receptor review gives a summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Request copy or view PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.