Vitamin D Receptors

Supporting information

Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney.

VDRs repress expression of 1α-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. Inherited mutations in the VDR gene leads to rickets, which is characterized by muscle weakness, growth retardation, bone deformity and secondary hyperparathyroidism. The human gene encoding the vitamin D receptor has been localized to chromosome 12q12-q14.

To view external sources of pharmacological information for Vitamin D Receptors, please click here: BJP Guide

View all products for Vitamin D Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Vitamin D Receptor Human VDR NM_000376 P11473
Mouse Vdr NM_009504 P48281
Rat Vdr NM_017058 P13053

Literature for Vitamin D Receptors

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
Request copy | Download PDF | View all Product Guides & Listings
Nuclear Receptors Product Listing

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Bio-Techne Events

WCI 2017

13th World Congress on Inflammation

July 8 - 12, 2017

London, UK