Vitamin D Receptors
Vitamin D receptors (VDRs) are members of the NR1I family, which also includes pregnane X receptors (PXR) and constitutive androstane receptors (CAR). They form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney.
VDRs repress expression of 1α-hydroxylase (the proximal activator of 1,25(OH)2D3) and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Also, it has recently been identified as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. Inherited mutations in the VDR gene leads to rickets, which is characterized by muscle weakness, growth retardation, bone deformity and secondary hyperparathyroidism. The human gene encoding the vitamin D receptor has been localized to chromosome 12q12-q14.
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|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|Vitamin D Receptor||Human||VDR||NM_000376||P11473|
Literature for Vitamin D Receptors
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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- Receptor Signaling
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A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
- Androgen Receptors
- Estrogen Receptors
- Retinoic Acid Receptors
- Retinoid X Receptors
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