Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. There are two closely related isoforms of each of these enzymes; LXRα and LXRβ, and FXRα and FXRβ (pseudogene in man).
LXRα and FXRα expression is restricted to the liver, small intestine, kidney and adrenal gland, whilst LXRβ and FXRβ are ubiquitously expressed. Despite acting on some of the same target genes, including cholesterol 7α-hydroxylase (CYP7A1) and SREBP-1c, LXRs and FXRs have different physiological roles. LXRs are involved in cholesterol homeostasis, inhibition of proinflammatory gene expression in atherosclerosis and activation of innate immunity, whilst FXRs have a vital function in bile acid homeostasis.
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Literature for LXR-like Receptors
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
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