LXR-like Receptors

Supporting information

Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor subfamily, which form heterodimers with members of the retinoid X receptor family. There are two closely related isoforms of each of these enzymes; LXRα and LXRβ, and FXRα and FXRβ (pseudogene in man).

LXRα and FXRα expression is restricted to the liver, small intestine, kidney and adrenal gland, whilst LXRβ and FXRβ are ubiquitously expressed. Despite acting on some of the same target genes, including cholesterol 7α-hydroxylase (CYP7A1) and SREBP-1c, LXRs and FXRs have different physiological roles. LXRs are involved in cholesterol homeostasis, inhibition of proinflammatory gene expression in atherosclerosis and activation of innate immunity, whilst FXRs have a vital function in bile acid homeostasis.

To view external sources of pharmacological information for LXR-like Receptors, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
LXRα Human NR1H3 NM_001130101 Q13133
Mouse Nr1h3 NM_013839 Q9Z0Y9
Rat Nr1h3 NM_031627 Q5I035
LXRβ Human NR1H2 NM_007121 P55055
Mouse Nr1h2 NM_009473 Q60644
Rat Nr1h2 NM_031626 Q62755
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Literature for LXR-like Receptors

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Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

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