Cytokine Receptors

Supporting information

Cytokine receptors are a large family of receptors that are grouped into six categories: type I, type II, immunoglobulin superfamily, tumor necrosis factor family, chemokine and TGF-β receptors.

  1. Type I cytokine receptors: include the IL-2 receptor, growth hormone receptor and erythropoietin receptor, are linked to JAK tyrosine kinases.
  2. Type II cytokine receptors: include interferon receptors are also linked to JAK tyrosine kinases.
  3. Immunoglobulin superfamily receptors: also classed as cell adhesion molecules, and family members include the IL-1 and IL-18 receptors.
  4. The tumor necrosis factor family: also known as death receptors as they have a role in the extrinsic apoptotic pathway.
  5. Chemokine receptors: G-protein-coupled receptors that have a role in innate and adaptive immunity.
  6. TGF-β receptors: serine/threonine kinase-coupled receptors with a role in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death.
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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
IL-2Rα Human IL2RA NM_000417 P01589
Mouse Il2ra NM_008367 P01590
Rat Il2ra NM_013163 P26897
IL-2Rβ Human IL2RB NM_000878 P14784
Mouse Il2rb NM_008368 P16297
Rat Il2rb NM_013195 P26896
View all Cytokine Receptor Gene Data »

Literature for Cytokine Receptors

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
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Immunology Product Listing
Pain Life Science Poster

Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.

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Pain Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

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IVBM 2016

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