Receptor Serine/Threonine Kinases (RSTKs)

Receptor serine/threonine kinases (RSTKs) are a group of related catalytic receptors that includes TGF-β receptors (TGF-βRI-III) and activin receptors (ALK1-7). RSTKs exist as heterodimers of type I and type II receptors and the ligand binding domain is located in the type II receptor. Upon ligand-receptor binding, the type I receptors are recruited to the complex and are phosphorylated by the type II receptor.

Receptor Serine/Threonine Kinase (RSTK) Target Files

Related Categories

SMAD proteins are subsequently phosphorylated by activated type I receptors, which are specific to the subtype of RSTK; TGF-βR and ALK4/5/7 phosphorylate Smad2/3, whilst ALK1/2/3/6 phosphorylate Smad1/5/8. Activated Smads associate with Smad4 and are transported to the nucleus to regulate expression of specific genes. Transcription factors and co-factors form a complex with Smad and are responsible for gene expression. There are many human diseases caused by dysregulation of RSTK signaling. These include gastrointestinal, pancreatic and pituitary malignancies, embryonic left-right axis malformation, aortic aneurysm and Loeys-Dietz syndrome.

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.