MET Receptors

Supporting information

The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for the MET receptor is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells.

In the adult, MET receptor expression is limited to stem and progenitor cells and is necessary for wound healing and hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are essential for invasive growth and mediate epithelial-mesenchymal transition (EMT).

Aberrant activation of the HGF/MET pathway leads to a variety of cancers. MET receptor mutations are associated with poor prognosis as they can trigger tumor growth, angiogenesis and metastasis.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human MET NM_000245 P08581
Mouse Met NM_008591 P16056
Rat Met NM_031517 P97523

Literature for MET Receptors

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Angiogenesis Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinases Product Listing

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VEGF Pathway & Anti-Angiogenic Therapy

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A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

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