Trk Receptors

Supporting information

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCγ signaling pathways. There are four members of the Trk family: TrkA, TrkB, TrkC and a related p75NTR receptor. p75NTR lacks tyrosine kinase activity and signals via NF-κB activation.

Each family member binds different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is involved in differentiation and survival of neurons, as well as in control of gene expression of enzymes involved in neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors with high affinity and retains low affinity to the mature cleaved forms.

TrkA was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

To view external sources of pharmacological information for Trk Receptors, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TrkA Human NTRK1 NM_002529 Q9UIU7
Mouse Ntrk1 NM_001033124 Q3UFB7
Rat Ntrk1 NM_021589 Q9JIW7
TrkB Human NTRK2 NM_001018064 Q16620
Mouse Ntrk2 NM_008745 P15209
Rat Ntrk2 NM_012731 Q63604
View all Trk Receptor Gene Data »

Literature for Trk Receptors

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Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.

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Parkinson's Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

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Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Peripheral Sensitization

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Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

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Parkinson's disease: Neurobiology and Therapeutic Strategies

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Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

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Antidepressants - Current and Future Targets

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Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

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Huntington's Disease: Pathophysiology and Clinical Prospects

Huntington's Disease Life Science Poster

Our Huntington's Disease (HD) poster summarizes the medium spiny neuron intracellular signaling pathways implicated in the pathology of HD. Request copy or view PDF today.

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