Epithelial Sodium Channels

Supporting information

Epithelial sodium channels (ENaCs) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels. They are highly selective Na+ channels that are localized to polarized epithelial cells. ENaCs are responsible for sodium reabsorption in the distal kidney tubule, and have similar functions in the alveoli and the colon. These channels transport Na+ across the epithelium using energy from Na+, K+-ATPase, and constitute one of the essential mechanisms in regulation of sodium balance, blood volume and blood pressure.

There are four ENaC subunits; α, β, γ and δ, which form functional heterotetramers. The kidney ENaC is thought to be a heterotetramer of 2α:1β:1γ.

ENaCs are tonically open at rest. Ion flux is regulated by aldosterone-, vasopressin- and glucocorticoid-mediated changes in ENaC gene transcription and phosphatidylinositides act to stabilize the channel.

To view external sources of pharmacological information for Epithelial Sodium Channels, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Epithelial Sodium Channels »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ENaCα Human SCNN1A NM_001038 P37088
Mouse Scnn1a NM_011324 Q61180
Rat Scnn1a NM_031548 P37089
ENaCβ Human SCNN1B NM_000336 P51168
Mouse Scnn1b NM_011325 Q9WU38
Rat Scnn1b NM_012648 Q9QUI8
View all Epithelial Sodium Channel Gene Data »

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