IP3 Receptors

Supporting information

Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.

IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

To view external sources of pharmacological information for IP3 Receptors, please click here: BJP Guide

View all products for IP3 Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
IP3R1 Human ITPR1 NM_002222 Q14643
Mouse Itpr1 NM_010585 P11881
Rat Itpr1 NM_001007235 Q5BJS8
IP3R2 Human ITPR2 NM_002223 Q14571
Mouse Itpr2 NM_019923 Q9Z329
Rat Itpr2 NM_031046 Q6W3E4
View all IP3 Receptor Gene Data »

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