Cholinesterases

Supporting information

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver. The high enzymatic rate of AChE means that it effectively terminates signal transmission at cholinergic synpases.

AChE is the target of organophosphate nerve agents such as sarin and VX. Clinically, AChE inhibitors have found a number of uses, with physostigmine used to treat glaucoma. AChE inhibitors are also used in the management of mild to moderate Alzheimer's disease.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Acetylcholin-esterase Human ACHE NM_015831 P22303
Mouse Ache NM_009599 P21836
Rat Ache NM_172009 P37136
Butyrylcholin-esterase Human BCHE NM_000055 P06276
Mouse Bche NM_009738 Q03311
Rat Bche NM_022942 Q9JKC1

Literature for Cholinesterases

Neurodegeneration Product Guide

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Alzheimer's Life Science Poster

Written by Alan Palmer and updated in 2015, this poster summarizes structural and functional changes observed in the progression of Alzheimer's disease (AD), as well as classic AD drug targets. The hypotheses behind the neurobiology of AD are discussed alongside the different stages in disease progression. Compounds available from Tocris are listed.

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Alzheimer's Life Science Poster

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Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

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Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

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