Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue.
There are two types of elastases; pancreatic elastase (E.C. 220.127.116.11) and leukocyte elastase (also known as neutrophil elastase) (E.C. 18.104.22.168). Pancreatic elastase is a digestive enzyme secreted from the pancreatic acinar cells and exists in a complex with α1-antitrypsin. Leukocyte elastase is a cytoplasmic enzyme that modifies the function of natural killer cells, monocytes and granulocytes. It specifically cleaves Val-X, Ala-X, Leu-X or Met-X peptide bonds.
Elastases have a physiological role in processes such as neutrophil migration, phagocytosis and tissue remodeling, and are known to contribute to the pathology of pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.View all products for Elastases »
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