Supporting information

Elastases are a group of serine proteases that specifically degrade elastin. Elastin, together with collagen, is a key protein that contributes to the mechanical properties of connective tissue.

There are two types of elastases; pancreatic elastase (E.C. and leukocyte elastase (also known as neutrophil elastase) (E.C. Pancreatic elastase is a digestive enzyme secreted from the pancreatic acinar cells and exists in a complex with α1-antitrypsin. Leukocyte elastase is a cytoplasmic enzyme that modifies the function of natural killer cells, monocytes and granulocytes. It specifically cleaves Val-X, Ala-X, Leu-X or Met-X peptide bonds.

Elastases have a physiological role in processes such as neutrophil migration, phagocytosis and tissue remodeling, and are known to contribute to the pathology of pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.

View all products for Elastases »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Elastase 1 Human ELA1 NM_001971 Q9UNI1
Mouse Ela1 NM_033612 NP_291090
Rat Ela1 NM_012552 P00773
Elastase 2 Human ELA2 NM_001972 P08246
Mouse Ela2 NM_015779 Q3UP87
Rat Ela2 NM_001106767 XP_234883
View all Elastase Gene Data »

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