Calpains

Supporting information

Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with μ-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation.

Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

View all products for Calpains »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Calpain 1 Human CAPN1 NM_005186 P07384
Mouse Capn1 NM_007600 O35350
Rat Capn1 NM_019152 P97571
Calpain 2 Human CAPN2 NM_001748 P17655
Mouse Capn2 NM_009794 O08529
Rat Capn2 NM_017116 Q07009
View all Calpain Gene Data »

Literature for Calpains

Apoptosis Signaling Pathway
Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

View pathway | Download PDF

Quick Order

Find multiple products by catalog number

divider line

Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.