Decarboxylases

Supporting information

Decarboxylases are a group of enzymes that remove carboxyl groups (CO2H) from acidic substrates and require pyridoxal phosphate or pyruvate as a co-factor. They are known for their various roles in metabolic pathways, non-oxidative decarboxylation of α- and β-keto acids and carbohydrate synthesis.

There are multiple members of this group, including ornithine decarboxylase (ODC) (EC: 4.1.1.17), which is involved in the urea cycle and L-aromatic amino-acid decarboxylase (AADC) (EC: 4.1.1.28), which is involved in conversion of L-dopa to dopamine and 5-HTP to serotonin.

To view external sources of pharmacological information for Decarboxylases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ODC Human ODC1 NM_002539 P11926
Mouse Odc1 NM_013614 P00860
Rat Odc1 NM_012615 P09057
AADC Human DDC NM_001082971 P20711
Mouse Ddc NM_016672 O88533
Rat Ddc NM_016672 Q3TUH2
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Literature for Decarboxylases

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