Decarboxylases are a group of enzymes that remove carboxyl groups (CO2H) from acidic substrates and require pyridoxal phosphate or pyruvate as a co-factor. They are known for their various roles in metabolic pathways, non-oxidative decarboxylation of α- and β-keto acids and carbohydrate synthesis.
There are multiple members of this group, including ornithine decarboxylase (ODC) (EC: 18.104.22.168), which is involved in the urea cycle and L-aromatic amino-acid decarboxylase (AADC) (EC: 22.214.171.124), which is involved in conversion of L-dopa to dopamine and 5-HTP to serotonin.
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