Dihydrofolate Reductase

More Information »Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR has a key role in cell growth and proliferation.

Dihydrofolate Reductase Products

Inhibitors
Cat.No.
Product Name / Activity
1230 Methotrexate
Dihydrofolate reductase inhibitor
6185 Pemetrexed
High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART
3918 Pyrimethamine
DHFR inhibitor; also potent inhibitor of multidrug and toxin extrusion (MATE) transporters and STAT3 inhibitor

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