Heme Oxygenase

Supporting information

Heme oxygenase (HO) catalyzes the degradation of heme. This membrane-bound enzyme cleaves the heme ring at the α-methene bridge to produce bilverdin (which is metabolized further by bilirubin reductase to form bilirubin), iron and the putative neurotransmitter, carbon monoxide.

There are three isoforms of heme oxygenase; the inducible HO-1, which is active at high concentrations of heme and at times of physiological stress, the constitutively active HO-2 and the non-catalytic HO-3, which is thought to function as an oxygen sensor. Heme oxygenase is localized to microsomes and the endoplasmic reticulum, and the enzyme is found at very high concentrations in splenocytes due to their function in the degradation of senescent erythrocytes.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
HO-1 Human HMOX1 NM_002133 P09601
Mouse Hmox1 NM_010442 P14901
Rat Hmox1 NM_012580 P06762
HO-2 Human HMOX2 NM_001127205 P30519
Mouse Hmox2 NM_010443 O70252
Rat Hmox2 NM_024387 P23711
HO-3 Rat HMOX3 NM_001077436 O70453

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