Cytochrome P450

Supporting information

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate and reduction of water. This group of enzymes contain a heme iron within the active site, which is essential for catalytic activity.

CYPs have been found in all organisms tested and are ubiquitously expressed. They are found at high levels in the liver, where they have an important role in metabolism of drugs and endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis, cholesterol synthesis and vitamin D metabolism.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CYP1A1 Human CYP1A1 NM_000499 P04798
Mouse Cyp1a1 NM_009992 P00184
Rat Cyp1a1 NM_012540 P00185
CYP1A2 Human CYP1A2 NM_000761 P05177
Mouse Cyp1a2 NM_009993 P00186
Rat Cyp1a2 NM_012541 P04799
View all Cytochrome P450 Gene Data »

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