Guanylyl Cyclases

Supporting information

Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. The second messenger cGMP participates in signaling by stimulating protein kinase G enzymes, altering the conductance of cGMP-gated ion channels and changing the activity of cGMP-regulated phosphodiesterases.

There are two main groups of guanylyl cyclase; soluble GC (sGC), which are the receptor for nitric oxide (NO) and transmembrane GC (pGC), which serves as a receptor for natriuretic peptides. Key physiological roles for guanylyl cyclases include regulation of cell hyperplasia, hypertrophy, migration, extracellular matrix production, cell differentiation and tumor progression. In addition, guanylyl cyclases mediate important communication between the heart, intestine and kidney to regulate blood volume and Na+ balance.

To view external sources of pharmacological information for Guanylyl Cyclases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
GUCY1α2 Human GUCY1A2 NM_000855 P33402
Mouse Gucy1a2 NM_001033322 NP_001028494
Rat Gucy1a2 NM_023956 Q9WVI4
GUCY1α3 Human GUCY1A3 NM_000856 Q02108
Mouse Gucy1a3 NM_021896 Q9ERL9
Rat Gucy1a3 NM_017090 P19686
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Literature for Guanylyl Cyclases

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