Cyclases

The cyclase enzymes, adenylyl cyclase and guanylyl cyclase, convert ATP and GTP to cAMP and cGMP respectively, plus pyrophosphate. These enzymes are important in the production of second messenger molecules and so have a vital role in signal transduction in a variety of physiological processes.

Cyclase Target Files

Related Categories
Subtype Endogenous Activators Endogenous Inhibitors
AC1 Ca2+/Calmodulin
PKC-evoked phosphorylation
Gαi
AC2 Gβγ
PKC-evoked phosphorylation
-
AC3 Ca2+/Calmodulin
PKC-evoked phosphorylation
Gαi
CaMKII-evoked phosphorylation
AC4 Gβγ PKC-evoked phosphorylation
AC5 PKC-evoked phosphorylation Gαi
Ca2+
PKA-evoked phosphorylation
AC6 - Gαi
Ca2+
PKA-evoked phosphorylation
PKC-evoked phosphorylation
AC7 PKC-evoked phosphorylation -
AC8 Ca2+ -
AC9 - Ca2+/calcineurin

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