Syk Kinase

Supporting information

Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Human SYK NR_024155 P43405
Mouse Syk NM_011518 P48025
Rat Syk NM_012758 Q63614

Literature for Syk Kinase

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

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Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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