Cdc25 Phosphatase

Supporting information

Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - Cdc25A, B and C. Cdc25 activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA damage checkpoints.

Regulation of Cdc25 occurs through a variety of mechanisms including phosphorylation, interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further phosphorylated in an auto-amplification loop, along with Cdc25C, by the CDK1/cyclin B complex. Cdc25C is also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex. Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex. Both Cdc25A and Cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit mitosis.

Cdc25 is a key mediator of cell cycle progression. Consequently, there is a strong link between Cdc25 and cancer. Expression of Cdc25A and Cdc25B is upregulated in certain cancer types, frequently those with more aggressive tumors and poor prognosis; the development of specific Cdc25 inhibitors is therefore of great therapeutic interest.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Cdc25A Human CDC25A NM_001789 P30304
Mouse Cdc25a NM_007658 P48964
Rat Cdc25a NM_133571 P48965
Cdc25B Human CDC25B NM_021874 P30305
Mouse Cdc25b NM_023117 P30306
Rat Cdc25b NM_133572 P48966
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Literature for Cdc25 Phosphatase

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