Rho-Kinases

Supporting information

Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases that are activated by RhoA GTPases, and are key modulators of processes involving cytoskeletal rearrangement such focal adhesion formation, cell motility and tumor cell invasion. There are two isoforms of ROCK, ROCKI (aka ROKβ or p160ROCK) and ROCKII (aka ROKα), which share a high degree of structural identity in their kinase domains (92%).

The two Rho-kinase isoforms have different patterns of tissue expression; ROCKII expression is highest in the brain and in muscle whereas ROCKI has a ubiquitous tissue distribution. Subcellularly, ROCKII is found in the cytosol and localizes to the cleavage furrow during cytokinesis. ROCKI is thought to colocalize with the centrosomes. ROCKs phosphorylate a number of proteins involved in actin filament assembly and contraction (e.g. LIM Kinases, MLCK, ERM proteins). Other downstream targets of the Rho kinases include signal transduction molecules such as IRS-1 and PI 3-K/AKT.

To view external sources of pharmacological information for Rho-Kinases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ROCKI (ROKβ, p160ROCK) Human ROCK1 NM_005406 Q13464
Mouse Rock1 NM_009071 P70335
Rat Rock1 NM_031098 Q63644
ROCKII (ROKα) Human ROCK2 NM_004850 O75116
Mouse Rock2 NM_009072 P70336
Rat Rock2 NM_013022 Q62868

Literature for Rho-Kinases

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
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Cardiovascular Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
Angiogenesis Life Science Poster

Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.

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Angiogenesis Life Science Poster

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

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Bio-Techne Events

ASCB 2016

ASCB 2016

December 3 - 7, 2016

San Francisco, CA,

Booth: 314