Rho-Kinases

Supporting information

Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases that are activated by RhoA GTPases, and are key modulators of processes involving cytoskeletal rearrangement such focal adhesion formation, cell motility and tumor cell invasion. There are two isoforms of ROCK, ROCKI (aka ROKβ or p160ROCK) and ROCKII (aka ROKα), which share a high degree of structural identity in their kinase domains (92%).

The two Rho-kinase isoforms have different patterns of tissue expression; ROCKII expression is highest in the brain and in muscle whereas ROCKI has a ubiquitous tissue distribution. Subcellularly, ROCKII is found in the cytosol and localizes to the cleavage furrow during cytokinesis. ROCKI is thought to colocalize with the centrosomes. ROCKs phosphorylate a number of proteins involved in actin filament assembly and contraction (e.g. LIM Kinases, MLCK, ERM proteins). Other downstream targets of the Rho kinases include signal transduction molecules such as IRS-1 and PI 3-K/AKT.

To view external sources of pharmacological information for Rho-Kinases, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ROCKI (ROKβ, p160ROCK) Human ROCK1 NM_005406 Q13464
Mouse Rock1 NM_009071 P70335
Rat Rock1 NM_031098 Q63644
ROCKII (ROKα) Human ROCK2 NM_004850 O75116
Mouse Rock2 NM_009072 P70336
Rat Rock2 NM_013022 Q62868

Literature for Rho-Kinases

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Kinases Product Listing

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Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
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Kinases Product Listing

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Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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