Kisspeptin Receptor

Supporting information

The kisspeptin receptor (also known as the KISS1 receptor) is a Gq/G11-protein-coupled receptor that signals through stimulation of phospholipase C resulting in Ca2+ mobilization. The kisspeptin receptor is found at high concentrations in the pancreas, placenta and brain and there are lower expression levels in the small intestine, kidney, lung, liver and heart.

The kisspeptin receptor plays a key role in the neuroendocrine control of the gonadotrophin axis and has been implicated in the inhibition of metastasis. The human KISS1 receptor gene is localized on chromosome 19p13.3.

To view external sources of pharmacological information for Kisspeptin Receptor, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human KISS1R NM_032551 Q969F8
Mouse Kiss1r NM_053244 Q91V45
Rat Kiss1r NM_023992 Q924U1

Literature for Kisspeptin Receptor

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