Motilin Receptor

Supporting information

The motilin receptor is a Gq/11-protein-coupled receptor that mediates progastrokinetic effects. It is found at its highest concentrations in the nerves of the antral wall of the stomach and is also found at significant levels throughout the smooth muscle of the upper GI tract and in the enteric nervous system.

The motilin receptor promotes gastric emptying after food intake and increases smooth muscle contraction in the GI tract. The motilin receptor has not been identified in rodents, but has been cloned in rabbits and humans. The human motilin receptor gene is localized on chromosome 13q14-q21.

To view external sources of pharmacological information for Motilin Receptor, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human MLNR NM_001507 O43193

Literature for Motilin Receptor

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