Platelet-Activating Factor (PAF) Receptors

Supporting information

Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response. PAF-R is linked to multiple intracellular signaling pathways, including the p38 MAPK and PI 3-K pathways, through increasing intracellular calcium mobilization, increasing IP3 synthesis and decreasing cAMP formation.

PAF-R has a wide biological distribution with high expression levels in the spleen and skeletal muscles and lower concentrations in the small intestine, lung, heart and liver. The human gene encoding the PAF-R is located on chromosome 1p35-34.3

To view external sources of pharmacological information for Platelet-Activating Factor (PAF) Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Platelet-Activating Factor (PAF) Receptors »
Species Gene Symbol Gene Accession No. Protein Accession No.
Human PTAFR NM_000952 P25105
Mouse Ptafr NM_001081211 Q62035
Rat Ptafr NM_053321 P46002

Literature for Platelet-Activating Factor (PAF) Receptors

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Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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