Sphingosine-1-Phosphate Receptors

Supporting information

Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes.

Both the SIP1 and SIP3 receptors are expressed ubiquitously. The SIP2 receptor is expressed postnatally in the brain, heart, lung, stomach, intestine and adrenal gland. The expression of SIP4 and SIP5 is less widespread, and confined to lymphoid tissue and white matter respectively.

S1P receptors couple to different G proteins to mediate a range of biological effects; Gi/o modulates cellular survival, proliferation and motility; G12/13 modulates cytoskeletal remodeling and cell-shape changes; and Gq modulates a range of cellular effector functions.

To view external sources of pharmacological information for Sphingosine-1-Phosphate Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Sphingosine-1-Phosphate Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
S1P1 Human S1PR1 NM_001400 P21453
Mouse S1pr1 NM_007901 O08530
Rat S1pr1 NM_017301 P48303
S1P2 Human S1PR2 NM_004230 O95136
Mouse S1pr2 NM_010333 P52592
Rat S1pr2 NM_017192 P47752
View all Sphingosine-1-Phosphate Receptor Gene Data »

Literature for Sphingosine-1-Phosphate Receptors

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Written by Yongping Crawford and Napoleone Ferrara, this poster highlights major targets for antiangiogenic therapy, namely tumor- and stromal cell-derived pathways. Intrinsic and acquired resistance are described; antiangiogenic therapies targeting the VEGF pathway are also summarized. Compounds available from Tocris are listed.

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Angiogenesis Life Science Poster

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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GPCR Product Listing

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Highlights over 450 products for GPCRs. Request copy or view PDF today.

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VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

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