Purinergic (P2Y) Receptors

Supporting information

P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known as a leukotriene B4 receptor.

P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCβ, PLD, PLA2, AC and MAPK/MEK kinase.

P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, epithelial cell communication and migration, as well as immune response.

To view external sources of pharmacological information for Purinergic (P2Y) Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Purinergic (P2Y) Receptors »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
P2Y1 Human P2RY1 NM_002563 P47900
Mouse P2ry1 NM_008772 P49650
Rat P2ry1 NM_012800 P49651
P2Y2 Human P2RY2 NM_176072 P41231
Mouse Pyry2 NM_008773 P35383
Rat P2ry2 NM_017255 P41232
View all P2Y Receptor Gene Data »

Literature for Purinergic (P2Y) Receptors

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
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Cardiovascular Research Product Guide
GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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GPCR Product Listing
Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
P2X and P2Y Receptors Scientific Review

A review of the subtypes and structures of P2 receptor families and the pharmacological probes used to study them. Compounds available from Tocris are listed.

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P2X and P2Y Receptors Scientific Review
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Cardiovascular Life Science Poster

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

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P2 Receptors Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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